Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators
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چکیده
منابع مشابه
Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators
The development of subunit vaccines has become very attractive in recent years due to their superior safety profiles as compared to traditional vaccines based on live attenuated or whole inactivated pathogens, and there is an unmet medical need for improved vaccines and vaccines against pathogens for which no effective vaccines exist. The subunit vaccine technology exploits pathogen subunits as...
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D espite a myriad of advances in the understanding and development of vaccine formulations, safe and effective vaccines have yet to be discovered for many pathogens. An excellent example of such is the malarial parasite Plasmodium vivax. Not only does this parasite transition between both extracellular and intracellular states during infection, but it can remain dormant in the liver and have gr...
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In the development of subunit vaccines with purified or recombinant antigens for cancer and infectious diseases, the design of improved and safe adjuvants able to efficiently target the antigen presenting cells, such as dendritic cells, represents a crucial challenge. Nanoparticle-based antigen delivery systems have been identified as an innovative strategy to improve the efficacy of subunit va...
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Brucellosis is a well-known infection in domestic animals which caused by Brucella bacterium. Due toserious economic and medical consequences of this disease, various efforts have been made to prevent theinfection through the use of recombinant vaccines based on Brucella outer membrane protein (OMP)antigens. The objectives of the present study were cloning, sequencing and epitope prediction of ...
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Introduction: Subunit vaccines represent an important aspect of modern vaccination. In this respect, the possibility to construct peptide-based vaccines is particularly appealing and peptides that e.g. mimic epitopes of pathogens, can be designed to induce well-defined monofunctional immune responses. Multi-epitopic constructs that contain epitopes from the same and/or different pathogen(s) can...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2016
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics8010007